Although the last few seasons of Dexter were flawed (to say the least), the entire series still possesses some entertainment value and one can marvel at the performance by Michael C. Hall who was pretty consistent even in those weaker seasons.
Overall, I suppose if you have nothing better to watch on a Saturday night, you certainly could to worse than The Guilt Trip, plus if you’re a fan of either Rogen or Streisand, you might enjoy a bit more than I did. In the end, the movie does contain a couple of laughs and the pairing of the two stars was well done, but the script fails.